Metabolic regulation and redox activity as mechanisms for angioprevention by dietary phytochemicals
نویسندگان
چکیده
منابع مشابه
Regulation of inflammation and redox signaling by dietary polyphenols.
Reactive oxygen species (ROS) play a key role in enhancing the inflammation through the activation of NF-kappaB and AP-1 transcription factors, and nuclear histone acetylation and deacetylation in various inflammatory diseases. Such undesired effects of oxidative stress have been found to be controlled by the antioxidant and/or anti-inflammatory effects of dietary polyphenols such as curcumin (...
متن کاملBiofilm prevention and control by dietary phytochemicals
A. Borges, A. C. Abreu, J. Malheiro, M. J. Saavedra and M. Simões LEPAE-Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465, Porto, Portugal CECAV-University of Trás-os-Montes e Alto Douro, Quinta de Prados, Apartado 1013, 5001-801, Vila Real, Portugal Department of Veterinary Sciences, School of Agriculture and Veterinary Scienc...
متن کاملRedox regulation in metabolic programming and inflammation
Energy metabolism and redox state are intrinsically linked. In order to mount an adequate immune response, cells must have an adequate and rapidly available energy resource to migrate to the inflammatory site, to generate reactive oxygen species using NADPH as a cofactor and to engulf bacteria or damaged tissue. The first responder cells of the innate immune response, neutrophils, are largely d...
متن کاملRedox and metabolic regulation of transcription
Reactive oxygen species (ROS) production and the resultant shift in the cellular redox state can exert a biphasic effect on cellular functions such as survival, migration or proliferation. At high levels, ROS can induce broad DNA and protein damage which can result in cell death, but at lower levels ROS act as signaling molecules that sustain proliferation or activate specific stress-response p...
متن کاملXenohormesis mechanisms underlying chemopreventive effects of some dietary phytochemicals.
A wide variety of phytochemicals present in our diet, including fruits, vegetables, and spices, have been shown to possess a broad range of health-beneficial properties. The cytoprotective and restorative effects of dietary phytochemicals are likely to result from the modulation of several distinct cellular signal transduction pathways. Many dietary phytochemicals that are synthesized as second...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2009
ISSN: 0020-7136,1097-0215
DOI: 10.1002/ijc.24677